纺锤体：微管与马达蛋白的动态组合。

The spindle: a dynamic assembly of microtubules and motors.

作者信息

Wittmann T, Hyman A, Desai A

机构信息

Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

Nat Cell Biol. 2001 Jan;3(1):E28-34. doi: 10.1038/35050669.

DOI:10.1038/35050669

PMID:11146647

Abstract

In all eukaryotes, a microtubule-based structure known as the spindle is responsible for accurate chromosome segregation during cell division. Spindle assembly and function require localized regulation of microtubule dynamics and the activity of a variety of microtubule-based motor proteins. Recent work has begun to uncover the molecular mechanisms that underpin this process. Here we describe the structural and dynamic properties of the spindle, and introduce the current concepts regarding how a bipolar spindle is assembled and how it functions to segregate chromosomes.

摘要

在所有真核生物中，一种称为纺锤体的基于微管的结构负责细胞分裂过程中染色体的精确分离。纺锤体的组装和功能需要对微管动力学进行局部调控以及多种基于微管的运动蛋白的活性。最近的研究工作已开始揭示这一过程背后的分子机制。在这里，我们描述纺锤体的结构和动态特性，并介绍关于双极纺锤体如何组装以及如何发挥作用来分离染色体的当前概念。