Subchronic oral toxicity of a combination of insecticide (HCH) and herbicide (ISP) in male rats.

作者信息

Raizada R B, Srivastava M K, Kaushal R A, Singh R P, Gupta K P

机构信息

Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre. Mahatma Gandhi Marg. PO Box 80. Lucknow 226001. India. intox.itrc.sirnet.ernet.in

出版信息

J Appl Toxicol. 2001 Jan-Feb;21(1):75-9. doi: 10.1002/jat.733.

DOI:10.1002/jat.733

PMID:11180283

Abstract

Rats were treated orally with technical hexachlorocyclohexane (HCH, 12.5, 25 and 50 mg kg-1 day(-1)) and technical isoproturon (ISP 22.5. 45 and 90 mg kg-1 day(-1)) daily for a period of 90 days alone and in combination. Treatment with HCH alone showed mild to severe toxicity and death. Significant changes occurred in liver weight, clinical enzyme profiles, haematological parameters and pathomorphological changes. Treatment with ISP alone did not produce such changes. The combination of HCH and ISP produced changes not suggestive of synergism.

摘要