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在内科和外科治疗的胃食管反流病患者中医疗资源的使用:一项基于人群的研究。

Use of healthcare resources among medically and surgically treated patients with gastroesophageal reflux disease: a population-based study.

作者信息

Holzman M D, Mitchel E F, Ray W A, Smalley W E

机构信息

Department of Surgery, Vanderbilt University and Nashville Veteran Affairs Medical Center, TN, USA.

出版信息

J Am Coll Surg. 2001 Jan;192(1):17-24. doi: 10.1016/s1072-7515(00)00746-8.

Abstract

BACKGROUND

Gastroesophageal reflux disease (GERD) is a common disorder that may be effectively managed medically or surgically. Direct evaluations of medical resource use are needed to better understand the relative costs of these alternatives. This study compared medical care use for a group of patients receiving surgical treatment for GERD with that for a comparable group of patients receiving medical management.

STUDY DESIGN

We conducted a retrospective matched cohort study of Tennessee Medicaid (TennCare) patients with GERD undergoing surgical treatment in 1996 and a group of patients who received medical therapy during the same period. Administrative TennCare data provided computerized records that could be used to identify patients and measure healthcare use. There were 7,502 people who met all of the conditions for inclusion in the study, including at least two encounters with a diagnosis of GERD. One hundred thirty-five of these who underwent fundoplication constituted the surgically treated cohort. The 250 persons in the medically treated cohort were selected randomly from the remaining nonsurgical patients and matched to the surgical cohort by age, gender, race, managed care organization, and acid suppression drug use in the baseline year. The principal outcome of interest was total use of medical resources, including prescription medication.

RESULTS

The surgical and medical cohorts did not differ significantly by demographic characteristics or by baseline use of pharmaceuticals. During the baseline year the surgically treated patients were prescribed 302 (95% CI: 270-334) days ofGERD treatment and the matched medical patients were prescribed 292 (95% CI: 267-317) days of GERD treatment. Surgically treated patients used more GERD-related outpatient resources (physician visits and diagnostic testing) in the baseline year, particularly in the 3 months before operation, when they had a mean of more than four outpatient encounter-days. In the followup year, use of GERD-related pharmaceuticals decreased markedly in the surgical cohort. These patients were prescribed an average of 123 days (95% CI: 94-153) of therapy, which was only 36% of that for medical patients (339 days [95% CI: 308-370]). More than 29% of surgical patients were prescribed no GERD-related drugs in the followup year compared with 6% of the medically treated group. The mean number of inpatient days for the fundoplication procedure was 3.2 (95% CI: 2.7-3.6), with a range of 0 to 13 days. There were no differences between the two groups in other healthcare use.

CONCLUSIONS

Our results show that in a 1-year period of followup, surgical treatment of severe gastroesophageal reflux disease led to a 64% postsurgical reduction in GERD medication use, with no increase in use of other medical services.

摘要

背景

胃食管反流病(GERD)是一种常见疾病,可通过药物或手术有效治疗。需要对医疗资源的使用进行直接评估,以更好地了解这些替代方案的相对成本。本研究比较了一组接受GERD手术治疗的患者与一组接受药物治疗的可比患者的医疗服务使用情况。

研究设计

我们对1996年接受手术治疗的田纳西医疗补助计划(TennCare)GERD患者以及同期接受药物治疗的一组患者进行了回顾性匹配队列研究。TennCare的管理数据提供了可用于识别患者和衡量医疗服务使用情况的计算机化记录。共有7502人符合纳入研究的所有条件,包括至少两次被诊断为GERD。其中135例接受胃底折叠术的患者构成手术治疗队列。药物治疗队列中的250人从其余非手术患者中随机选择,并根据年龄、性别、种族、管理式医疗组织和基线年份的抑酸药物使用情况与手术队列进行匹配。主要关注的结果是医疗资源的总使用情况,包括处方药。

结果

手术队列和药物治疗队列在人口统计学特征或基线药物使用方面没有显著差异。在基线年份,接受手术治疗的患者被开具GERD治疗药物的天数为302天(95%可信区间:270 - 334天),匹配的药物治疗患者为292天(95%可信区间:267 - 317天)。接受手术治疗的患者在基线年份使用了更多与GERD相关的门诊资源(医生就诊和诊断测试),特别是在手术前3个月,此时他们平均有超过4个门诊就诊日。在随访年份,手术队列中与GERD相关药物的使用显著减少。这些患者平均被开具123天(95%可信区间:94 - 153天)的治疗药物,仅为药物治疗患者的36%(339天[95%可信区间:308 - 370天])。随访年份中,超过29%的手术患者未被开具与GERD相关的药物,而药物治疗组为6%。胃底折叠术的平均住院天数为3.2天(95%可信区间:2.7 - 3.6天),范围为0至13天。两组在其他医疗服务使用方面没有差异。

结论

我们的结果表明,在1年的随访期内,严重胃食管反流病的手术治疗导致术后GERD药物使用减少64%,且其他医疗服务的使用没有增加。

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