FR131535，一种新型水溶性棘白菌素样脂肽：合成及生物学特性
FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties.
作者信息
Fujie A, Iwamoto T, Sato B, Muramatsu H, Kasahara C, Furuta T, Hori Y, Hino M, Hashimoto S
机构信息
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
出版信息
Bioorg Med Chem Lett. 2001 Feb 12;11(3):399-402. doi: 10.1016/s0960-894x(00)00677-6.
Abstract
The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379.
摘要
描述了一种新型水溶性棘白菌素样脂肽FR131535的合成及其生物学特性。该化合物在体外和体内均表现出强大的抗真菌活性。通过替换酰基侧链降低了FR901379的溶血活性。该化合物表现出良好的水溶性，与天然产物FR901379相当。
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