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MICE,一个用于在动物设施中追踪和监测动物的程序。

MICE, a program to track and monitor animals in animal facilities.

作者信息

Boulukos K E, Pognonec P

机构信息

IFR 72, Centre de Biochimie, Université de Nice, Parc Valrose, 06108 Nice cedex 2, France.

出版信息

BMC Genet. 2001;2:4. doi: 10.1186/1471-2156-2-4. Epub 2001 Mar 8.

Abstract

BACKGROUND

A growing number of laboratories are using the mouse as a model system in developmental biology as well as in molecular biology. Surprisingly, most of these laboratories do not have reliable computerized systems to track these animals, and the few commercial solutions available are expensive. We thus developed MICE (Mouse Information and Classification Entity), a program aimed at facilitating the monitoring of animals in animal facilities.

RESULTS

This program consists of a virtual facility in which scientists can perform all the tasks done in the real world (i.e., receiving animals, breeding them, preparing cage labels, etc.). Recording of each animal (birth date, cage number, ID number, tail analysis number, parents, genetic status, genetic background, etc.) enables reliable tracking. According to any parameter of interest, animals can then be identified, grouped, sorted, moved, and so forth. Crossings are automatically processed by the program. For example, new genetic backgrounds, generation number, and anticipated due dates are determined. The program also reminds the user when new births are expected and entering newborn animals only requires a few clicks. The genealogy of each animal can be determined in two different ways, one being the visualization of a genealogical tree from which information of ancestors can be retrieved.

CONCLUSION

This standalone program, that will be distributed free of charge to academic laboratories requesting a license, represents a new and valuable tool for all animal facility users, and permits simple and reliable tracking and retrieving of animals.

摘要

背景

越来越多的实验室在发育生物学和分子生物学中使用小鼠作为模型系统。令人惊讶的是,这些实验室中的大多数没有可靠的计算机系统来追踪这些动物,而现有的少数商业解决方案价格昂贵。因此,我们开发了MICE(小鼠信息与分类实体)程序,旨在方便对动物设施中的动物进行监测。

结果

该程序包括一个虚拟设施,科学家可以在其中执行在现实世界中完成的所有任务(即接收动物、繁殖它们、准备笼子标签等)。记录每只动物的信息(出生日期、笼子编号、ID编号、尾巴分析编号、父母、遗传状态、遗传背景等)可实现可靠的追踪。根据任何感兴趣的参数,然后可以识别、分组、分类、移动动物等等。该程序会自动处理交配情况。例如,确定新的遗传背景、代数和预期预产期。该程序还会在预期有新出生动物时提醒用户,输入新生动物只需点击几下。每只动物的谱系可以通过两种不同的方式确定,一种是可视化谱系树,从中可以检索祖先的信息。

结论

这个独立的程序将免费分发给申请许可证的学术实验室,它是所有动物设施用户的一个新的有价值的工具,允许简单可靠地追踪和检索动物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6121/29084/039646c00444/1471-2156-2-4-1.jpg

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