In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography.
作者信息
Aboagye E O., Price P M., Jones T
机构信息
PET Oncology Group Department of Cancer Medicine, Imperial College School of Medicine MRC Cyclotron Unit, Hammersmith Hospital Du Cane Road, W12 0NN, London, UK
出版信息
Drug Discov Today. 2001 Mar 1;6(6):293-302. doi: 10.1016/s1359-6446(01)01684-1.
Abstract
Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.
摘要
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