一种探究糖缀合物中跨域立体化学通讯自主性的策略。

A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates.

作者信息

Live D H, Wang Z G, Iserloh U, Danishefsky S J

机构信息

Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

Org Lett. 2001 Mar 22;3(6):851-4. doi: 10.1021/ol0070233.

DOI:10.1021/ol0070233

PMID:11263898

Abstract

Glycoproteins contain carbohydrate and peptide sectors. As a model for studying whether there exists stereochemical "communication" between the two domains, we prepared two glycopeptides differing only in the absolute stereochemistry of the peptide domain (L-peptide vs D-peptide). High-field NMR spectroscopy revealed that there are distinct and measurable differences, indicating that the two domains are at some level interactive.

摘要

糖蛋白含有碳水化合物和肽段。作为研究这两个结构域之间是否存在立体化学“通讯”的模型，我们制备了两种仅在肽段结构域的绝对立体化学上不同的糖肽（L-肽与D-肽）。高场核磁共振光谱显示存在明显且可测量的差异，表明这两个结构域在某种程度上是相互作用的。