啮齿动物物种中大鼠X染色体基因顺序的保守性。

Conservation of the rat X chromosome gene order in rodent species.

作者信息

Kuroiwa A, Tsuchiya K, Watanabe T, Hishigaki H, Takahashi E, Namikawa T, Matsuda Y

机构信息

Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.

出版信息

Chromosome Res. 2001;9(1):61-7. doi: 10.1023/a:1026795717658.

DOI:10.1023/a:1026795717658

PMID:11272793

Abstract

We constructed the comparative cytogenetic maps of X chromosomes in three rodent species, Indian spiny mouse (Mus platythrix), Syrian hamster and Chinese hamster, using 26 mouse cDNA clones. Twenty-six, 22 and 22 out of the 26 genes, which were mapped to human, mouse and rat X chromosomes in our previous study, were newly localized to X chromosomes of Indian spiny mouse, and Syrian and Chinese hamsters, respectively. The order of the genes aligned on the long arm of human X chromosome was highly conserved in rat and the three rodent species except mouse. The present results suggest a possibility that the rat X chromosome retains the ancestral form of the rodent X chromosomes.

摘要

我们使用26个小鼠cDNA克隆构建了三种啮齿动物——印度刺毛鼠（Mus platythrix）、叙利亚仓鼠和中国仓鼠X染色体的比较细胞遗传学图谱。在我们之前的研究中，这26个基因中有26个、22个和22个分别被定位到人类、小鼠和大鼠的X染色体上，而现在它们分别新定位到了印度刺毛鼠、叙利亚仓鼠和中国仓鼠的X染色体上。在大鼠以及除小鼠外的三种啮齿动物中，排列在人类X染色体长臂上的基因顺序高度保守。目前的结果表明，大鼠X染色体有可能保留了啮齿动物X染色体的原始形式。