Sur M, Cooper K, Allard U
Department of Anatomical Pathology, University of the Witwatersrand, Johannesburg, South African Institute for Medical Research.
Pathology. 2001 Feb;33(1):17-20.
To investigate the prevalence of human papillomavirus in transitional cell carcinoma of the urinary bladder in South Africa.
Ninety-one archival samples of bladder transitional cell carcinoma were subjected to polymerase chain reaction (PCR) and non-isotopic in situ hybridisation (NISH) for the detection of human papillomavirus 6, 11, 16, 18, 31, and 33 genotypes.
HPV was detected in only one case with PCR. HPV was not detected in any of the cases subjected to the NISH system.
This study shows that although HPV has been shown to be associated with uterine cervical and esophageal squamous cell carcinomas in South Africa, this virus is not present in the transitional cell carcinoma of the urinary bladder in this geographical location. It is suggested that other factors, including nitrosamine exposure, p53 mutation, and additional unknown chromosomal events, may play a role in the carcinogenesis of this neoplasm in the bladder.
调查南非膀胱移行细胞癌中人乳头瘤病毒的患病率。
对91份膀胱移行细胞癌存档样本进行聚合酶链反应（PCR）和非同位素原位杂交（NISH），以检测人乳头瘤病毒6、11、16、18、31和33基因型。
仅1例通过PCR检测到HPV。在接受NISH检测的任何病例中均未检测到HPV。
本研究表明，尽管在南非人乳头瘤病毒已被证明与子宫颈癌和食管鳞状细胞癌有关，但在该地理位置的膀胱移行细胞癌中不存在这种病毒。建议其他因素，包括亚硝胺暴露、p53突变和其他未知的染色体事件，可能在膀胱这种肿瘤的致癌过程中起作用。
