全胃肠外营养与胆汁淤积

Total parenteral nutrition and cholestasis.

作者信息

Sandhu I S, Jarvis C, Everson G T

机构信息

Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Denver, Colorado, USA.

出版信息

Clin Liver Dis. 1999 Aug;3(3):489-508, viii. doi: 10.1016/s1089-3261(05)70082-9.

DOI:10.1016/s1089-3261(05)70082-9

PMID:11291236

Abstract

Hepatobiliary dysfunction is recognized as a major adverse effect of total parenteral nutrition (TPN). It is unknown if this is caused by a deficiency or toxicity of the TPN solution or the underlying pathophysiology of disease processes that require TPN therapy. This article presents algorithms for evaluating abnormal liver tests in patients on TPN and discusses treatment options and the current status of intestinal transplantation.

摘要

肝胆功能障碍被认为是全胃肠外营养（TPN）的主要不良反应。目前尚不清楚这是由TPN溶液的缺乏或毒性引起的，还是由需要TPN治疗的疾病过程的潜在病理生理学引起的。本文介绍了评估接受TPN治疗患者肝功能异常的算法，并讨论了治疗选择以及肠道移植的现状。