Musini S, Savazzi G M
Dipartimento di Clinica Medica e Nefrologia, Università, Parma.
Recenti Prog Med. 2001 Feb;92(2):117-20.
Antiphospholipid antibodies (aPL) are an eterogeneous group of immunoglobulins, that include lupus anticoagulant and anticardiolipin antibodies. Patients with aPL are at high risk of venous and arterial thrombosis, thrombocytopenia and recurrent fetal loss. Antiphospholipid antibodies should be suspected in case of unexplained thrombophilia and prolongation of coagulation assays (aPTT); infact although such antibodies present an anticoagulant effect in vitro, in vivo the interfere with physiological anticoagulant reactions and may have a procoagulant effect. This paper deals with a case report characterized by a poor sintomatology, a short bleeding, but a spread of abnormal laboratoristic findings that give us the opportunity to investigate an uncommon syndrome.
抗磷脂抗体(aPL)是一组异质性免疫球蛋白,包括狼疮抗凝物和抗心磷脂抗体。aPL患者有发生静脉和动脉血栓形成、血小板减少和反复流产的高风险。在出现不明原因的血栓形成倾向和凝血试验(活化部分凝血活酶时间)延长时,应怀疑抗磷脂抗体;事实上,尽管此类抗体在体外呈现抗凝作用,但在体内它们会干扰生理性抗凝反应,可能具有促凝作用。本文报道了一例症状不典型、出血时间短,但实验室检查结果异常广泛的病例,这使我们有机会研究一种罕见综合征。