香港肺炎链球菌对大环内酯类药物的耐药性
Macrolide resistance in Streptococcus pneumoniae in Hong Kong.
作者信息
Ip M, Lyon D J, Yung R W, Chan C, Cheng A F
机构信息
Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
出版信息
Antimicrob Agents Chemother. 2001 May;45(5):1578-80. doi: 10.1128/AAC.45.5.1578-1580.2001.
Abstract
Erythromycin resistance rates among penicillin-susceptible Streptococcus pneumoniae were 38 and 92% among penicillin-intermediate and -resistant S. pneumoniae isolates from Hong Kong, respectively, and 27% (43 of 158) of the isolates showed the MLS(B) phenotype, and the majority carried the ermB gene; 73% (115 of 158) displayed the M phenotype, and all possessed the mef gene. The MLS(B) phenotype was predominant in penicillin-susceptible, macrolide-resistant isolates and in penicillin-nonsusceptible isolates of serotype 6B, whilst the M phenotype was predominant in penicillin-intermediate or -resistant isolates belonging to serotype 23F or 19F. Extensive spread of clones of drug-resistant pneumococci has led to the widespread presence of macrolide resistance in S. pneumoniae in Hong Kong.
摘要
在香港，对青霉素敏感的肺炎链球菌中红霉素耐药率分别为38%，对青霉素中介和耐药的肺炎链球菌分离株中该耐药率分别为92%，27%（158株中的43株）的分离株表现出MLS(B)表型，且大多数携带ermB基因；73%（158株中的115株）表现出M表型，且均拥有mef基因。MLS(B)表型在对青霉素敏感、对大环内酯类耐药的分离株以及6B血清型对青霉素不敏感的分离株中占主导，而M表型在属于23F或19F血清型的对青霉素中介或耐药的分离株中占主导。耐药肺炎球菌克隆的广泛传播导致香港肺炎链球菌中大环内酯类耐药普遍存在。
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