Ng K P, Saw T L, Na S L, Soo-Hoo T S
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Mycopathologia. 2001;149(3):141-6. doi: 10.1023/a:1007283211220.
A total of 102 Candida species were isolated from blood cultures from January 1997 to October 1999. Using assimilation of carbohydrate test, 52 (51.0%) of the Candida sp. were identified as C. parapsilosis, 25.5% (26) were C. tropicalis. C. albicans made up 11.8% (12), 6.9% (7) were C. rugosa, 3.8% (4) C. glabrata and 1% (1) C. guilliermondii. No C. dubliniensis was found in the study. In vitro antifungal susceptibility tests showed that all Candida species were sensitive to nystatin, amphotericin B and ketoconazole. Although all isolates remained sensitive to fluconazole, intermediate susceptibility was found in 3 C. rugosa isolates. Antifungal agents with high frequency of resistance were econazole, clotrimazole, miconazole and 5-fluorocytosine. Candida species found to have resistance to these antifungal agents were non-C. albicans.
1997年1月至1999年10月期间，共从血培养中分离出102株念珠菌。通过碳水化合物同化试验，52株（51.0%）念珠菌被鉴定为近平滑念珠菌，25.5%（26株）为热带念珠菌。白色念珠菌占11.8%（12株），皱落念珠菌占6.9%（7株），光滑念珠菌占3.8%（4株），季也蒙念珠菌占1%（1株）。研究中未发现都柏林念珠菌。体外抗真菌药敏试验表明，所有念珠菌对制霉菌素、两性霉素B和酮康唑敏感。虽然所有分离株对氟康唑仍敏感，但在3株皱落念珠菌分离株中发现了中度敏感性。耐药频率较高的抗真菌药物是益康唑、克霉唑、咪康唑和5-氟胞嘧啶。发现对这些抗真菌药物耐药的念珠菌为非白色念珠菌。
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