反应性和克隆性血小板增多症：促炎和造血细胞因子及急性期蛋白。
Reactive and clonal thrombocytosis: proinflammatory and hematopoietic cytokines and acute phase proteins.
作者信息
Araneda M, Krishnan V, Hall K, Kalbfleisch J, Krishnaswamy G, Krishnan K
机构信息
Department of Internal Medicine, James H. Quillen VA Medical Center and James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA.
出版信息
South Med J. 2001 Apr;94(4):417-20.
BACKGROUND
We quantitated proinflammatory and thrombopoietic cytokines in reactive thrombocytosis (RT) and clonal thrombocytosis (CT) to identify a cytokine profile that might aid in the distinction of these two disorders.
METHODS
Serum levels of cytokines relevant to platelet biology--interleukins 3, 6, 11, and 1beta; thrombopoietin; tumor necrosis factor alpha; and C-reactive protein (CRP)--were measured by enzyme-linked immunosorbent assay in healthy subjects and in patients with CT and RT.
RESULTS
Interleukin-6 and CRP levels were higher in RT patients than in controls or CT patients. Interleukin 1beta levels were higher in the RT group than in the CT and control groups.
CONCLUSIONS
In RT, IL-6, IL-1beta, and CRP levels are elevated. In both RT and CT, IL-11 is elevated, but thrombopoietin levels are not.
背景
我们对反应性血小板增多症（RT）和克隆性血小板增多症（CT）中的促炎细胞因子和血小板生成细胞因子进行了定量分析，以确定有助于区分这两种疾病的细胞因子谱。
方法
采用酶联免疫吸附测定法，检测健康受试者、CT患者和RT患者血清中与血小板生物学相关的细胞因子水平——白细胞介素3、6、11和1β、血小板生成素、肿瘤坏死因子α和C反应蛋白（CRP）。
结果
RT患者的白细胞介素-6和CRP水平高于对照组或CT患者。RT组的白细胞介素1β水平高于CT组和对照组。
结论
在RT中，IL-6、IL-1β和CRP水平升高。在RT和CT中，IL-11均升高，但血小板生成素水平未升高。
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