脱氢表雄酮与右芬氟拉明或噻奈普汀联合使用的厌食作用。
Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine.
作者信息
Rowland N E, Marshall M, Robertson K
机构信息
Department of Psychology, University of Florida, P.O. Box 112250, Center Drive, Gainesville, FL 32611-2250, USA.
出版信息
Eur J Pharmacol. 2001 May 4;419(1):61-4. doi: 10.1016/s0014-2999(01)00958-x.
Free feeding rats given supplementary 1 h access per day to a palatable dessert test meal were tested for the anorectic effect of dehydroepiandrosterone alone or in combination with either the serotonin releasing agent dexfenfluramine or the norepinephrine uptake inhibitor thionisoxetine (LY 368975). Isobolographic analysis showed that the effect of dehydroepiandrosterone combined with either dexfenfluramine or thionisoxetine was within the range predicted for additivity of action.
给予自由进食的大鼠每天额外1小时进食美味甜点测试餐，以测试脱氢表雄酮单独使用或与5-羟色胺释放剂右芬氟拉明或去甲肾上腺素摄取抑制剂硫西汀（LY 368975）联合使用时的厌食作用。等效线图分析表明，脱氢表雄酮与右芬氟拉明或硫西汀联合使用的效果在预期的相加作用范围内。
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