粗糙皮毛小鼠（C3H/HeJ-ruf/ruf）被毛皮肤的组织学特征

Histological characteristics of the pelage skin of rough fur mice (C3H/HeJ- ruf/ruf).

作者信息

Park Y G, Hayasaka S, Takagishi Y, Inouye M, Okumoto M, Oda S

机构信息

Department of Laboratory Animal Science, Division of Veterinary Sciences, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan.

出版信息

Exp Anim. 2001 Apr;50(2):179-82. doi: 10.1538/expanim.50.179.

DOI:10.1538/expanim.50.179

PMID:11381623

Abstract

Pelage skin of C3H/HeJ mice homozygous at an autosomal recessive mutant locus, rough fur (ruf) which is located on chromosome 9, was histologically analyzed. Sebaceous glands synthesizing lipids were larger in the mutant mice than in controls in an examination by Sudan IV staining. Electron microscopic analysis of the sebaceous gland showed that lipid droplets were denser in mutant mice than in control mice, and that they were irregular in shape in ruf mice while those of controls were round. Our results suggested that rough fur (ruf) mice might be an animal model for hyperlipogenesis of the pelage skin.

摘要

对位于9号染色体上的常染色体隐性突变位点——粗糙被毛（ruf）纯合的C3H/HeJ小鼠的被毛皮肤进行了组织学分析。在通过苏丹IV染色检查时，合成脂质的皮脂腺在突变小鼠中比在对照小鼠中更大。对皮脂腺的电子显微镜分析表明，突变小鼠中的脂滴比对照小鼠中的更密集，并且在ruf小鼠中它们的形状不规则，而对照小鼠的脂滴是圆形的。我们的结果表明，粗糙被毛（ruf）小鼠可能是被毛皮肤高脂生成的动物模型。