de Haro L, Valli M, Bourdon J H, Iliadis A, Hayek-Lanthois M, Arditti J
Centre Antipoison, Hĵpital Salvator, Marseille, France.
Vet Hum Toxicol. 2001 Jun;43(3):174-5.
A 54-y-old man ingested 2 g of bulk laboratory diazepam and was treated with activated charcoal, enhanced diuresis and flumazenil infusion. The treatment resulted in awakening, but the patient had drowsiness, dysarthria, diplopia, and dizziness for 9 d. Blood levels of diazepam and its main metabolite, nordiazepam, were obtained for 1 mo. The half-lives in this benzodiazepine overdose were longer than those seen with therapeutic doses. Benzodiazepines should not be readministrated when patients awake after suicide attempts.
一名54岁男性摄入了2克散装实验室用安定，接受了活性炭、强化利尿及氟马西尼输注治疗。治疗后患者苏醒，但出现了9天的嗜睡、构音障碍、复视和头晕。在1个月内检测了安定及其主要代谢产物去甲安定的血药浓度。此次苯二氮䓬类药物过量的半衰期比治疗剂量时更长。自杀未遂患者苏醒后不应再次给予苯二氮䓬类药物。
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