Iversen T, Tretli S, Kringlen E
The Department of Oncology, Ullevaal Hospital, Oslo, Norway.
Br J Cancer. 2001 Jun 1;84(11):1463-5. doi: 10.1054/bjoc.2001.1827.
We have identified 23 334 individuals (40%) of twins born in Norway 1905-45 where both twins were alive in 1960 without malignant disease. These were linked to the Cancer Registry of Norway. A reduced risk of malignant disease was demonstrated among twins for all tumour sites combined; standardized incidence rate (SIR): 0.90 (95% CI 0.85-0.94) in females and 0.95 (95% Cl 0.90-0.99) in males. In both sexes, we observed a significant reduced incidence of malignant melanomas of the skin. The incidence of colorectal cancer tended to be reduced for both sexes. In females, the incidence of tumours of the central nervous system and lungs were reduced. We consider our findings are real, but cannot explain them.
我们识别出了1905年至1945年在挪威出生的双胞胎中的23334人(占40%),这些双胞胎在1960年时均存活且无恶性疾病。他们与挪威癌症登记处建立了关联。对于所有肿瘤部位综合起来看,双胞胎群体中患恶性疾病的风险降低;标准化发病率(SIR):女性为0.90(95%可信区间0.85 - 0.94),男性为0.95(95%可信区间0.90 - 0.99)。在两性中,我们都观察到皮肤恶性黑色素瘤的发病率显著降低。结直肠癌的发病率在两性中都有降低的趋势。在女性中,中枢神经系统和肺部肿瘤的发病率降低。我们认为我们的发现是真实的,但无法对其作出解释。