Knight R D, Shimeld S M
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading, RG6 6AJ, UK.
Genome Biol. 2001;2(5):RESEARCH0016. doi: 10.1186/gb-2001-2-5-research0016. Epub 2001 Apr 24.
Identification of orthologous relationships between genes from widely divergent taxa allows partial reconstruction of the gene complement of ancestral genomes. C2H2 zinc-finger genes are one of the largest and most complex gene superfamilies in metazoan genomes, with hundreds of members in the human genome. Here we analyze C2H2 zinc-finger genes from three taxa - Drosophila, Caenorhabditis elegans and human - from which near-complete genome sequence data are available.
Our analyses conclusively identify 39 families of genes, of which 38 can be defined as orthology groups in that they are descended from single ancestral genes in the common ancestor of Drosophila, C. elegans and humans.
On the basis of current metazoan phylogeny, these 39 groups represent the minimum complement of C2H2 zinc-finger genes present in the genome of the bilaterian common ancestor.
鉴定来自广泛不同分类群的基因之间的直系同源关系，有助于部分重建祖先基因组的基因组成。C2H2锌指基因是后生动物基因组中最大且最复杂的基因超家族之一，人类基因组中有数百个成员。在此，我们分析了来自三个分类群（果蝇、秀丽隐杆线虫和人类）的C2H2锌指基因，这些分类群都有近乎完整的基因组序列数据。
我们的分析最终确定了39个基因家族，其中38个可被定义为直系同源组，因为它们源自果蝇、秀丽隐杆线虫和人类共同祖先中的单个祖先基因。
基于当前的后生动物系统发育，这39个组代表了两侧对称动物共同祖先基因组中存在的C2H2锌指基因的最小组成。
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