Husa P, Chalupa P, Stroblová H, Husová L, Slesinger P, Zajíc J
Department of Infectious Diseases, University Hospital, Brno, Czech Republic.
Acta Virol. 2001 Feb;45(1):7-11.
The aim of this study was to determine the incidence of autoantibodies to asialoglycoprotein receptor (ASGPR, anti-ASGPR) in chronic hepatitis C patients and to characterize the anti-ASGPR-positive and anti-ASGPR-negative patients in more detail. A total of 79 chronic hepatitis C patients were screened for the presence anti-ASGPR by ELISA. Anti-ASGPR were detected in 11 (13.9%) patients. No significant differences were found between the anti-ASGPR-positive and anti-ASGPR-negative patients in age, alanine transaminase (ALT) activity, histological findings and response and tolerance to alpha-interferon (alpha-IFN) therapy. The male predominance in the anti-ASGPR positive group was statistically significant. It was surprising that other tested autoantibodies (antinuclear autoantibodies [ANA], smooth muscle autoantibodies [SMA], type 1 liver-kidney microsome autoantibodies [LKM-1], anti-thyroglobulin and thyroid microsome autoantibodies) and increased levels of immunoglobulins A, G and/or M were observed significantly more frequently in the anti-ASGPR-negative group.
本研究旨在确定慢性丙型肝炎患者中去唾液酸糖蛋白受体自身抗体（ASGPR，抗ASGPR）的发生率，并更详细地描述抗ASGPR阳性和抗ASGPR阴性患者的特征。通过酶联免疫吸附测定法（ELISA）对总共79例慢性丙型肝炎患者进行抗ASGPR检测。在11例（13.9%）患者中检测到抗ASGPR。抗ASGPR阳性和抗ASGPR阴性患者在年龄、丙氨酸转氨酶（ALT）活性、组织学检查结果以及对α干扰素（α-IFN）治疗的反应和耐受性方面未发现显著差异。抗ASGPR阳性组中男性占优势具有统计学意义。令人惊讶的是，在抗ASGPR阴性组中，其他检测的自身抗体（抗核抗体[ANA]、平滑肌抗体[SMA]、1型肝肾微粒体抗体[LKM-1]、抗甲状腺球蛋白和甲状腺微粒体抗体）以及免疫球蛋白A、G和/或M水平升高的情况明显更频繁地出现。
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