抗体依赖性细胞毒性介导的抗HIV-1抗体与HIV感染预后预测指标之间相关性的证据。
Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection.
作者信息
Ahmad R, Sindhu S T, Toma E, Morisset R, Vincelette J, Menezes J, Ahmad A
机构信息
Pediatric Research Center, Ste-Justine Hospital, Montreal, QC, Canada.
出版信息
J Clin Immunol. 2001 May;21(3):227-33. doi: 10.1023/a:1011087132180.
Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.
在HIV-1特异性抗体依赖性细胞毒性（ADCC）试验中，我们使用表达gp120/41且对NK细胞活性具有抗性的CEM.NKR细胞克隆作为靶标，在此证明抗HIV-1 ADCC抗体的血清滴度与外周血CD4 + T细胞计数呈显著正相关（P < 0.05），与HIV感染个体血浆中HIV-1 RNA的拷贝数呈负相关。这些发现强调了这些抗体作为这些感染中保护性免疫参数的重要性。
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