5,6,11,12-四氢吲哚并[2,3-α]咔唑衍生物的合成、表征及药理活性

Synthesis, characterization and pharmacological activities of 5,6,11,12-tetrahydroindolo[2,3-alpha]carbazole derivatives.

作者信息

Balamurali R, Prasad K J

机构信息

Department of Chemistry, Bharathiar University, Coimbatore 641 046, India.

出版信息

Farmaco. 2001 Mar;56(3):229-32. doi: 10.1016/s0014-827x(01)01035-7.

DOI:10.1016/s0014-827x(01)01035-7

PMID:11409331

Abstract

A series of new 5,6,11,12-tetrahydroindolo[2,3-alpha]carbazole derivatives (3a-h) was synthesized. Treatment of 8-methyl-1-oxo-1,2,3,4-tetrahydrocarbazole (1a) with phenylhydrazine hydrochloride in ethanol furnished the title compound (3a) in poor yield along with 8-methyl-1-phenylhydrazono-1,2,3,4-tetrahydrocarbazole (2a). Better yields were obtained when 1a-h were treated with phenylhydrazine in glacial acetic acid. All the newly synthesized compounds were characterized on the basis of IR, NMR, mass-spectra and elemental analysis and screened for pharmacological activities.

摘要

合成了一系列新的5,6,11,12-四氢吲哚并[2,3-α]咔唑衍生物（3a-h）。在乙醇中用盐酸苯肼处理8-甲基-1-氧代-1,2,3,4-四氢咔唑（1a），以低产率得到标题化合物（3a）以及8-甲基-1-苯肼基-1,2,3,4-四氢咔唑（2a）。当1a-h在冰醋酸中用苯肼处理时可获得更高的产率。所有新合成的化合物均通过红外光谱、核磁共振、质谱和元素分析进行表征，并进行了药理活性筛选。