脐血转铁蛋白受体用于评估胎儿铁状态。
Cord blood transferrin receptors to assess fetal iron status.
作者信息
Sweet D G, Savage G A, Tubman R, Lappin T R, Halliday H L
机构信息
Royal Maternity Hospital, Grosvenor Road, Belfast BT12 6BB, Northern Ireland.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2001 Jul;85(1):F46-8. doi: 10.1136/fn.85.1.f46.
OBJECTIVE
To study iron status at different gestational ages using cord blood serum transferrin receptors (STfRs).
METHODS
STfRs, iron, ferritin, total iron binding capacity, haemoglobin, and reticulocytes were measured in 144 cord blood samples. The babies were divided into three groups according to gestation (26 very preterm (24-29 weeks); 50 preterm (30-36 weeks); 68 term (37-41 weeks)).
RESULTS
Serum iron, ferritin, and total iron binding capacity were highest at term, whereas reticulocytes were highest in the very preterm. STfR levels were not influenced by gestation. Haemoglobin (r = 0.46; p < 0.0001) and reticulocytes (r = 0.42; p < 0.0001) were the only indices that independently correlated with STfR levels.
CONCLUSIONS
STfR levels in cord blood are not directly influenced by gestation and probably reflect the iron requirements of the fetus for erythropoiesis.
目的
利用脐血血清转铁蛋白受体（STfRs）研究不同孕周的铁状态。
方法
检测144份脐血样本中的STfRs、铁、铁蛋白、总铁结合力、血红蛋白和网织红细胞。根据孕周将婴儿分为三组（26例极早产儿（24 - 29周）；50例早产儿（30 - 36周）；68例足月儿（37 - 41周））。
结果
血清铁、铁蛋白和总铁结合力在足月儿中最高，而网织红细胞在极早产儿中最高。STfR水平不受孕周影响。血红蛋白（r = 0.46；p < 0.0001）和网织红细胞（r = 0.42；p < 0.0001）是仅与STfR水平独立相关的指标。
结论
脐血中的STfR水平不受孕周直接影响，可能反映胎儿红细胞生成的铁需求。
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