反射性交感神经营养不良中多灶性或全身性强直性肌张力障碍的临床特征

Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy.

作者信息

van Hilten J J, van de Beek W J, Vein A A, van Dijk J G, Middelkoop H A

机构信息

Department of Neurology, Leiden University Medical Center, the Netherlands.

出版信息

Neurology. 2001 Jun 26;56(12):1762-5. doi: 10.1212/wnl.56.12.1762.

DOI:10.1212/wnl.56.12.1762

PMID:11425951

Abstract

The authors describe 10 patients with reflex sympathetic dystrophy that progressed to a multifocal or generalized tonic dystonia. The neuropsychologic profile was similar to that of other patients with chronic pain, irrespective of its cause. The distribution pattern of dystonia, the stretch reflex abnormalities, and the worsening of dystonia after tactile and auditory stimuli suggest impairment of interneuronal circuits at the brainstem or spinal level. Antibody titers for glutamic acid decarboxylase, tetanus, and Sjögren antigens were all normal.

摘要

作者描述了10例反射性交感神经营养不良进展为多灶性或全身性强直性肌张力障碍的患者。神经心理学特征与其他慢性疼痛患者相似，无论其病因如何。肌张力障碍的分布模式、牵张反射异常以及触觉和听觉刺激后肌张力障碍的加重提示脑干或脊髓水平的中间神经元回路受损。谷氨酸脱羧酶、破伤风和干燥综合征抗原的抗体滴度均正常。