狂犬病病毒中和性人单克隆抗体在暴露后预防中的实验效用

Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis.

作者信息

Hanlon C A, DeMattos C A, DeMattos C C, Niezgoda M, Hooper D C, Koprowski H, Notkins A, Rupprecht C E

机构信息

Centers for Disease Control and Prevention, Rabies Section MS-G33, 1600 Clifton Road NE, Atlanta, GA 30333, USA.

出版信息

Vaccine. 2001 Jul 16;19(28-29):3834-42. doi: 10.1016/s0264-410x(01)00135-9.

DOI:10.1016/s0264-410x(01)00135-9

PMID:11427255

Abstract

Rabies immune globulin (RIG) is essential for post-exposure prophylaxis but is expensive and not widely available. Rabies virus-neutralizing human monoclonal antibodies (Mabs) were evaluated in vitro and in a Syrian hamster model as a potential future alternative. Seven Mabs neutralized representative rabies virus variants. However, a European bat lyssavirus was not neutralized by either Mabs or RIG. Moreover, Duvenhage virus was neutralized by RIG, but not by Mabs, and Lagos bat and Mokola viruses were neutralized by one Mab but not by RIG. In hamsters, one Mab resulted in protection that was comparable to human RIG. These results suggest that Mabs may provide a promising alternative to RIG.

摘要

狂犬病免疫球蛋白（RIG）是暴露后预防所必需的，但价格昂贵且供应不广泛。狂犬病病毒中和人单克隆抗体（Mabs）在体外和叙利亚仓鼠模型中进行了评估，作为未来可能的替代物。七种单克隆抗体中和了代表性的狂犬病病毒变体。然而，一种欧洲蝙蝠狂犬病病毒既未被单克隆抗体也未被狂犬病免疫球蛋白中和。此外，杜文黑格病毒被狂犬病免疫球蛋白中和，但未被单克隆抗体中和，拉各斯蝙蝠病毒和莫科拉病毒被一种单克隆抗体中和，但未被狂犬病免疫球蛋白中和。在仓鼠中，一种单克隆抗体产生的保护作用与人狂犬病免疫球蛋白相当。这些结果表明，单克隆抗体可能为狂犬病免疫球蛋白提供一种有前景的替代物。