泛昔洛韦用于治疗亚洲象（印度象）内皮嗜性疱疹病毒感染。

Use of famciclovir for the treatment of endotheliotrophic herpesvirus infections in Asian elephants (Elephas maximus).

作者信息

Schmitt D L, Hardy D A, Montali R J, Richman L K, Lindsay W A, Isaza R, West G

机构信息

Southwest Missouri State University, Springfield 65804, USA.

出版信息

J Zoo Wildl Med. 2000 Dec;31(4):518-22. doi: 10.1638/1042-7260(2000)031[0518:UOFFTT]2.0.CO;2.

DOI:10.1638/1042-7260(2000)031[0518:UOFFTT]2.0.CO;2

PMID:11428400

Abstract

Two juvenile Asian elephants (Elephas maximus) presented with an acute onset of facial edema and lethargy. Examination of the oral cavity of each animal revealed cyanosis of the tip and distal margins of the tongue suggestive of endothelial inclusion body disease (EIBD) of elephants. Whole-blood samples were obtained, and polymerase chain reaction tests confirmed the presence of elephant herpesvirus. The animals were administered famciclovir (Famvir, SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania 19101, USA), a potent human anti-herpesvirus drug, in the course of their disease, and recovery followed a treatment regime of 3-4 wk. These are the first known cases of elephants surviving EIBD.

摘要

两头亚洲幼象（印度象）出现面部水肿和嗜睡的急性发作。对每头动物的口腔检查发现，舌尖和舌远端边缘发绀，提示大象患有内皮包涵体病（EIBD）。采集了全血样本，聚合酶链反应检测证实存在大象疱疹病毒。在患病过程中，给这些动物使用了泛昔洛韦（Famvir，史克必成制药公司，美国宾夕法尼亚州费城19101），一种强效的人类抗疱疹病毒药物，经过3 - 4周的治疗后康复。这些是已知的首例大象从EIBD中存活的病例。