Baden L R, Maguire J H
Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Infect Dis Clin North Am. 2001 Jun;15(2):639-70, xi. doi: 10.1016/s0891-5520(05)70163-x.
Gastrointestinal disease is a significant cause of morbidity and mortality in the immunocompromised patient. This article focuses on the infectious gastrointestinal complications associated with the treatment of malignant disease and with solid organ transplantation but not HIV. Gastrointestinal defenses and the various mechanisms by which they are impaired are reviewed. The major pathogens and malignancies of this patient population and an approach to their diagnosis, treatment, and prevention are discussed.
胃肠疾病是免疫功能低下患者发病和死亡的重要原因。本文重点关注与恶性疾病治疗及实体器官移植相关的感染性胃肠并发症,但不包括与艾滋病相关的并发症。本文回顾了胃肠道防御机制及其受损的各种途径。讨论了该患者群体的主要病原体和恶性肿瘤,以及对其进行诊断、治疗和预防的方法。