砂仁提取物通过抑制核因子κB激活对四氧嘧啶诱导的糖尿病的保护作用。

The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation.

作者信息

Park B H, Park J W

机构信息

Department of Biochemistry and Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, Korea.

出版信息

Exp Mol Med. 2001 Jun 30;33(2):64-8. doi: 10.1038/emm.2001.12.

DOI:10.1038/emm.2001.12

PMID:11460883

Abstract

This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum prevented alloxan-induced hyperglycemia and hypoinsulinemia in a dose dependent manner. Histological examination of pancreatic tissue from A. xanthoides extract treated mice showed that the islet cells remain unaffected by alloxan treatment. NFkappaB activation in the pancreas 30 min after alloxan injection (60 mg/kg, iv), as assessed by an electrophoretic mobility shift assay, was not detected in the mice pretreated with A. xanthoides extract. These results suggest that NFkappaB activation may be one of the critical determinant in the progression of the disease. Considering the preventive effect of A. xanthoides extract from alloxan-induced diabetics development, these results may provide the possible therapeutic value of A. xanthoides extract for the prevention of diabetes mellitus progression.

摘要

本研究旨在探讨山姜提取物对四氧嘧啶诱导的小鼠糖尿病发生的预防机制。通过腹腔注射山姜提取物对小鼠进行预处理，以剂量依赖的方式预防了四氧嘧啶诱导的高血糖和低胰岛素血症。对山姜提取物处理的小鼠胰腺组织进行组织学检查显示，胰岛细胞未受四氧嘧啶处理的影响。通过电泳迁移率变动分析评估，在注射四氧嘧啶（60 mg/kg，静脉注射）30分钟后，用山姜提取物预处理的小鼠胰腺中未检测到NFκB激活。这些结果表明，NFκB激活可能是该疾病进展的关键决定因素之一。考虑到山姜提取物对四氧嘧啶诱导的糖尿病发生的预防作用，这些结果可能为山姜提取物预防糖尿病进展提供潜在的治疗价值。