无机铅暴露工人淋巴细胞中铅暴露指标与姐妹染色单体交换（SCE）频率之间的相关性。

Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers.

作者信息

Duydu Y, Süzen H S, Aydin A, Cander O, Uysal H, Işimer A, Vural N

机构信息

University of Ankara, Faculty of Pharmacy, Department of Toxicology, 06100, Tandogan, Ankara, Turkey.

出版信息

Arch Environ Contam Toxicol. 2001 Aug;41(2):241-6. doi: 10.1007/s002440010244.

DOI:10.1007/s002440010244

PMID:11462150

Abstract

Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte delta-aminolevulinic acid dehydrogenase (ALAD) activity, urinary delta-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 microg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead.

摘要

对31名受雇于蓄电池厂的志愿者进行了无机铅暴露研究。通过姐妹染色单体交换（SCE）来测定铅的遗传毒性。还测定了红细胞δ-氨基乙酰丙酸脱氢酶（ALAD）活性、尿δ-氨基乙酰丙酸（U-ALA）和血铅水平（PbBs），以评估这些铅暴露指标与观察到的SCE频率之间的一些可能关系。测定出工人的血铅浓度平均水平为36.31微克/分升。因此，与对照组相比，在血铅水平统计学上更高时，观察到红细胞中ALAD活性降低，U-ALA排泄增加。在血铅水平与SCE频率之间观察到统计学上显著的相关性（p < 0.05）。此外，U-ALA排泄与SCE频率之间的相关性（p < 0.01）相对高于血铅水平与SCE频率之间的相关性。这些结果可能表明了ALA在铅的遗传毒性作用中的一种可能介导机制。