5-羟色胺1A受体激动剂8-羟基二丙胺基四氢萘（8-OH-DPAT）与多巴胺D2/3受体激动剂7-羟基二丙胺基四氢萘（7-OH-DPAT）对大鼠的叠加低温效应。

Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat.

作者信息

Eltayb A, Lindblom S, Oerther S, Ahlenius S

机构信息

Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.

出版信息

Acta Physiol Scand. 2001 Jul;172(3):205-9. doi: 10.1046/j.1365-201x.2001.00858.x.

DOI:10.1046/j.1365-201x.2001.00858.x

PMID:11472307

Abstract

The objective of this study was to examine possible interactions between serotonergic and dopaminergic agents lowering core temperature via stimulation of 5-HT1A and dopamine (DA) D2 receptors, respectively. The effects of the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin HBr (8-OH-DPAT) and the DA D2/3 receptor agonist 7-OH-DPAT on core temperature was monitored in adult male Wistar rats, approximately 300 g body weight. The temperature probe was connected to a PC-assisted temperature instrument, and an automated printer device was activated when the temperature reading had stabilized (+/-0.1 degrees C) for 10 s. As expected, 7-OH-DPAT [0.5 and 2.0 micromol x kg(-1) subcutaneous (s.c.)] as well as 8-OH-DPAT (0.15-2.4 micromol x kg(-1) s.c.), produced a dose-dependent hypothermia. When combined, there were additive effects of the two compounds, although the effects of 7-OH-DPAT were attenuated by 8-OH-DPAT at the higher doses (0.6-2.4 micromol x kg(-1)), in all probability because of emerging DA D2 receptor blocking properties of the latter compound.

摘要

本研究的目的是检测5-羟色胺能和多巴胺能药物之间可能的相互作用，这两种药物分别通过刺激5-HT1A和多巴胺（DA）D2受体来降低核心体温。在体重约300g的成年雄性Wistar大鼠中监测5-HT1A受体激动剂（±）-8-羟基-2-（二正丙基氨基）四氢萘溴化物（8-OH-DPAT）和DA D2/3受体激动剂7-OH-DPAT对核心体温的影响。温度探头连接到一台由计算机辅助的温度仪器上，当温度读数在（±0.1℃）稳定10秒后，自动打印装置启动。正如预期的那样，7-OH-DPAT[0.5和2.0μmol·kg-1皮下注射（s.c.）]以及8-OH-DPAT（0.15 - 2.4μmol·kg-1 s.c.）均产生剂量依赖性体温降低。当二者合用时，两种化合物产生相加作用，尽管在较高剂量（0.6 - 2.4μmol·kg-1）时，7-OH-DPAT的作用被8-OH-DPAT减弱，很可能是因为后一种化合物出现了DA D2受体阻断特性。