多聚内酯A和B，来自多毛炭角菌的新型抗真菌十元内酯。

Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex.

作者信息

Boonphong S, Kittakoop P, Isaka M, Pittayakhajonwut D, Tanticharoen M, Thebtaranonth Y

机构信息

Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

出版信息

J Nat Prod. 2001 Jul;64(7):965-7. doi: 10.1021/np000291p.

DOI:10.1021/np000291p

PMID:11473437

Abstract

Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC(50) values of 7 and 2 microg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 microg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 microg/mL).

摘要

从多毛炭角菌Xylaria multiplex BCC 1111的发酵液提取物中分离得到了两种新的十元内酯，即多聚内酯A（1）和B（2）。根据它们的光谱数据阐明了1和2的化学结构。多聚内酯A（1）和B（2）对白色念珠菌表现出抗真菌活性，IC(50)值分别为7和2微克/毫升。在筛选系统中，1和2对恶性疟原虫（浓度为20微克/毫升）均无活性，且对BC-1和KB细胞系（浓度为20微克/毫升）无细胞毒性。