感染性疾病期间Th1细胞和Th2细胞的分化：不同途径中的不对称性

Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways.

作者信息

Jankovic D, Liu Z, Gause W C

机构信息

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Rm 126, 4 Center Drive MSC 0425, Bethesda, MD 20892, USA.

出版信息

Trends Immunol. 2001 Aug;22(8):450-7. doi: 10.1016/s1471-4906(01)01975-5.

DOI:10.1016/s1471-4906(01)01975-5

PMID:11473835

Abstract

The development of T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to an infectious pathogen will lead to protection of the host or dissemination of the disease. Recent studies have suggested that this process is governed by distinct sets of signals provided by dendritic cells upon interactions with specific infectious agents. A model is proposed that links together the pathogen, the innate response and Th-cell polarization.

摘要

辅助性T细胞1（Th1）与辅助性T细胞2（Th2）的分化是免疫反应中的一个主要分支点。它是决定对感染性病原体的反应会导致宿主得到保护还是疾病传播的一个重要因素。最近的研究表明，这一过程受树突状细胞在与特定感染因子相互作用时提供的不同信号集所调控。本文提出了一个将病原体、固有免疫反应和Th细胞极化联系在一起的模型。