Williamson D H, Ellington E V
Biochem J. 1975 Jan;146(1):277-9. doi: 10.1042/bj1460277.
At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.
在浓度为2毫摩尔及以上时,尽管羟基丙酮酸能被快速利用,但分离出的大鼠肝细胞却不能利用它产生葡萄糖。在较低浓度的羟基丙酮酸条件下,或者在存在能产生还原当量的底物(乙醇或丁酸盐)时,羟基丙酮酸能生成可观量的葡萄糖。本文对这一现象的可能解释进行了讨论。