左旋多巴诱导的运动障碍的病理生理学：新疗法的潜力

Pathophysiology of levodopa-induced dyskinesia: potential for new therapies.

作者信息

Bezard E, Brotchie J M, Gross C E

机构信息

Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France.

出版信息

Nat Rev Neurosci. 2001 Aug;2(8):577-88. doi: 10.1038/35086062.

DOI:10.1038/35086062

PMID:11484001

Abstract

Involuntary movements--or dyskinesias--are a debilitating complication of levodopa therapy for Parkinson's disease, and is experienced in most patients. Despite the importance of this problem, little was known about the cause of dyskinesia until recently; however, this situation has changed significantly in the past few years. Our increased understanding of levodopa-induced dyskinesia is not only valuable for improving patient care, but also in providing us with new insights into the functional organization of the basal ganglia and motor systems.

摘要

非自主运动——即运动障碍——是帕金森病左旋多巴治疗中一种使人衰弱的并发症，大多数患者都会出现。尽管这个问题很重要，但直到最近人们对运动障碍的病因仍知之甚少；然而，在过去几年中这种情况发生了显著变化。我们对左旋多巴诱发的运动障碍有了更多了解，这不仅对改善患者护理很有价值，而且还为我们深入了解基底神经节和运动系统的功能组织提供了新的见解。