Noisakran S, Carr D J
Department of Ophthalmology, Microbiology, and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Immunol Res. 2001;24(1):1-11. doi: 10.1385/IR:24:1:01.
Herpes simplex virus (HSV) types 1 and 2 are highly successful human pathogens that can elicit blinding herpetic keratoconjunctivitis, fatal sporadic encephalitis, aseptic meningitis, and increase the risk of acquiring additional sexually transmitted diseases. Type I interferons (IFN) play a significant role in controlling HSV pathogenesis by antagonizing viral replication and spread. Taking advantage of the susceptibility of HSV to IFNs, a novel approach of employing plasmid DNA cassettes expressing type 1 IFNs to antagonize viral pathogenesis has been undertaken. This review will describe recent work in our lab and those of others using naked DNA encoding cytokines to antagonize HSV replication and virus trafficking or immune-mediated pathogenesis as a result of viral assault to ocular tissue.
单纯疱疹病毒1型和2型是非常成功的人类病原体，可引发致盲性疱疹性角膜结膜炎、致死性散发性脑炎、无菌性脑膜炎，并增加感染其他性传播疾病的风险。I型干扰素（IFN）通过拮抗病毒复制和传播在控制单纯疱疹病毒发病机制中发挥重要作用。利用单纯疱疹病毒对干扰素的敏感性，人们采用了一种新方法，即使用表达I型干扰素的质粒DNA盒来拮抗病毒发病机制。本综述将描述我们实验室以及其他实验室最近的工作，这些工作利用编码细胞因子的裸DNA来拮抗单纯疱疹病毒复制、病毒转运或因病毒侵袭眼组织而导致的免疫介导发病机制。
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