肌萎缩侧索硬化症患者对重复神经刺激递减反应的预后价值。
Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients.
作者信息
Wang F C, De Pasqua V, Gérard P, Delwaide P J
机构信息
University Department of Physical Medicine and Rehabilitation, Hôpital du Sart Tilman, Belgium.
出版信息
Neurology. 2001 Sep 11;57(5):897-9. doi: 10.1212/wnl.57.5.897.
Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year of riluzole therapy. The correlation between decrement and CMAP size reduction per year was highly significant (r = 0.77), but no relationship could be demonstrated between decrement and other variables. The authors thus propose that decrement after RNS may be used as a predictor of further drop in CMAP size.
在接受利鲁唑治疗前，对肌萎缩侧索硬化症（ALS）患者进行了评估，通过以3Hz的频率对正中神经进行重复神经刺激（RNS），测量大鱼际复合肌肉动作电位（CMAP）的衰减情况。在利鲁唑治疗1年前后，对CMAP大小以及运动单位数量和大小估计值进行了两次评估。衰减与每年CMAP大小减少之间的相关性非常显著（r = 0.77），但衰减与其他变量之间未显示出相关性。因此，作者提出，RNS后的衰减可作为CMAP大小进一步下降的预测指标。
Zotero 插件