双绒毛膜性与子痫前期。
Twin chorionicity and pre-eclampsia.
作者信息
Savvidou M D, Karanastasi E, Skentou C, Geerts L, Nicolaides K H
机构信息
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
出版信息
Ultrasound Obstet Gynecol. 2001 Sep;18(3):228-31. doi: 10.1046/j.0960-7692.2001.00470.x.
OBJECTIVE
To determine whether the incidence of pre-eclampsia is different in dichorionic compared to monochorionic twin pregnancies.
METHODS
The study involved 666 twin pregnancies resulting in two live births after 24 weeks of gestation. Ultrasound examination at 10-14 weeks of gestation demonstrated that 171 (25.7%) were monochorionic and 495 (74.3%) were dichorionic twins. Pregnancy outcome information regarding the development of pre-eclampsia was obtained from the maternity units. The incidence of pre-eclampsia in the dichorionic and monochorionic twin pregnancies was compared.
RESULTS
The incidence of pre-eclampsia in monochorionic twin pregnancies (9.4%) was not significantly different from that in dichorionic pregnancies (7.3%) ( P = 0.48). Multiple logistic regression revealed that chorionicity has no effect on the development of pre-eclampsia after adjusting for maternal age, ethnic group, maternal smoking, parity and gestational age at delivery ( P = 0.6; odds ratio for monochorionic compared with dichorionic twin pregnancies, 1.19; 95% confidence interval, 0.61-2.3).
CONCLUSION
In twin pregnancies chorionicity does not affect the incidence of pre-eclampsia.
目的
确定双绒毛膜双胎妊娠与单绒毛膜双胎妊娠相比，子痫前期的发生率是否存在差异。
方法
该研究纳入了666例双胎妊娠，这些妊娠在妊娠24周后分娩出两个活产儿。妊娠10 - 14周时的超声检查显示，171例（25.7%）为单绒毛膜双胎，495例（74.3%）为双绒毛膜双胎。从产科病房获取有关子痫前期发生情况的妊娠结局信息。比较双绒毛膜双胎妊娠和单绒毛膜双胎妊娠中子痫前期的发生率。
结果
单绒毛膜双胎妊娠中子痫前期的发生率（9.4%）与双绒毛膜双胎妊娠中子痫前期的发生率（7.3%）无显著差异（P = 0.48）。多因素logistic回归分析显示，在调整产妇年龄、种族、产妇吸烟情况、产次及分娩孕周后，绒毛膜性对子痫前期的发生无影响（P = 0.6；单绒毛膜双胎妊娠与双绒毛膜双胎妊娠相比的比值比为1.19；95%置信区间为0.61 - 2.3）。
结论
在双胎妊娠中，绒毛膜性不影响子痫前期的发生率。
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