Site-directed alkylation to cytidine within duplex by the oligonucleotides containing functional nucleobases.
作者信息
Nagatsugi F, Kawasaki T, Tokuda N, Maeda M, Sasaki S
机构信息
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):915-9. doi: 10.1081/NCN-100002458.
PMID:11563144
Abstract
We have previously described that oligonucleotides (ODN) containing phenylsulfoxide derivative of 2-amino-6-vinylpurine nucleoside analog (1) are activated within duplex to form cross-link toward cytidine selectively at the target site. In this paper, we wish to report the search for more stable precursor susceptible for activation within duplex.
摘要
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