琉球松茎皮中的三萜成分及其对DNA拓扑异构酶II的抑制作用。

Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect.

作者信息

Wada S I, Iida A, Tanaka R

机构信息

Osaka University of Pharmaceutical Sciences, Osaka, Japan.

出版信息

Planta Med. 2001 Oct;67(7):659-64. doi: 10.1055/s-2001-17360.

DOI:10.1055/s-2001-17360

PMID:11582546

Abstract

Nine lanostane and serratane-type triterpenes including two unknown compounds were isolated from the stem bark of Pinus luchuensis. These new compounds were characterized as 3-oxolanost-9(11)-ene-24S,25-diol (1) and 29-acetoxy-3beta-methoxyserrat-14-en-21alpha-ol (2) on the basis of spectroscopic evidence. Some of these triterpenes were tested for the inhibitory effect on DNA topoisomerase II activity. Compound 1 showed a slightly less potent inhibitory activity with an IC(50) value of 186 microM.

摘要

从琉球松的茎皮中分离出9种羊毛甾烷型和锯齿烷型三萜类化合物，其中包括2种未知化合物。基于光谱学证据，这些新化合物被鉴定为3-氧代羊毛甾-9(11)-烯-24S,25-二醇（1）和29-乙酰氧基-3β-甲氧基锯齿-14-烯-21α-醇（2）。对其中一些三萜类化合物进行了DNA拓扑异构酶II活性抑制作用测试。化合物1表现出稍弱的抑制活性，IC(50)值为186 microM。