结构基因组学之旅。

A tour of structural genomics.

作者信息

Brenner S E

机构信息

Department of Plant and Microbial Biology, University of California, 461A Koshland Hall, Berkeley, California 94720-3102, USA.

出版信息

Nat Rev Genet. 2001 Oct;2(10):801-9. doi: 10.1038/35093574.

DOI:10.1038/35093574

PMID:11584296

Abstract

Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models are expected to yield insight into the molecular function and mechanism of thousands of proteins. The pervasiveness of this information is likely to change the use of structure in molecular biology and biochemistry.

摘要

结构基因组学项目旨在为所有由完整基因组编码的可处理大分子提供实验性或计算性的三维模型结构。为此，全球的试点中心正在探索大规模结构测定的可行性。预计他们的实验结构和计算模型将有助于深入了解数千种蛋白质的分子功能和机制。这些信息的广泛应用可能会改变结构在分子生物学和生物化学中的使用方式。