肿瘤抑制中的INK4a/ARF网络

The INK4a/ARF network in tumour suppression.

作者信息

Sherr C J

机构信息

Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.

出版信息

Nat Rev Mol Cell Biol. 2001 Oct;2(10):731-7. doi: 10.1038/35096061.

DOI:10.1038/35096061

PMID:11584300

Abstract

The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

摘要

视网膜母细胞瘤蛋白（RB）和p53转录因子受INK4a/ARF基因座编码的两种不同蛋白质调控。在大多数人类癌症中，编码这四种肿瘤抑制因子的基因全部或部分失活。一个将RB和p53的活性相互联系起来的复杂信号网络监测致癌刺激，以提供一种细胞自主的肿瘤监测模式。