Kurosawa K, Takahashi K, Tsuda E
Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.
J Antibiot (Tokyo). 2001 Aug;54(8):615-21. doi: 10.7164/antibiotics.54.615.
Novel depsipeptides, SW-163C and E were isolated from the culture broth of an actinomycete strain. The producing organism, designated as SNA15896, was identified as a member of Streptomyces from its morphological and cultural characteristics. SW-163C and E exhibited potent antitumor activities against various tumor cell lines in vitro and against murine leukemia P388 in vivo. The compounds also showed antimicrobial activities.
从一株放线菌的培养液中分离出了新型缩肽SW-163C和E。产生这两种缩肽的菌株命名为SNA15896，根据其形态和培养特征鉴定为链霉菌属的一个成员。SW-163C和E在体外对多种肿瘤细胞系以及在体内对小鼠白血病P388均表现出强大的抗肿瘤活性。这些化合物还显示出抗菌活性。
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