枝孢菌素D，一种由枝孢菌FT-0012产生的新型12元大环内酯类抗生素。

Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012.

作者信息

Zhang H, Tomoda H, Tabata N, Miura H, Namikoshi M, Yamaguchi Y, Masuma R, Omura S

机构信息

The Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2001 Aug;54(8):635-41. doi: 10.7164/antibiotics.54.635.

DOI:10.7164/antibiotics.54.635

PMID:11592500

Abstract

A new antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed antifungal activity against Pyricularia oryzae and Mucor racemosus.

摘要

通过溶剂萃取、ODS柱色谱和制备型高效液相色谱法，从枝孢霉菌FT-0012的发酵液中分离出一种名为枝孢菌素D的新型抗生素，同时还分离出了已知的枝孢菌素A和B。枝孢菌素D的结构被推断为（E）-2-十二碳烯-5-羟基-11-内酯-4-酮。枝孢菌素D对稻瘟病菌和总状毛霉显示出抗真菌活性。