Hanson N, Leachman S
Department of Dermatology and Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City 84112, USA.
Semin Cutan Med Surg. 2001 Sep;20(3):166-83. doi: 10.1053/sder.2001.28209.
Isotretinoin (Accutane, Roche Laboratories Inc, Nutley, NJ) is an important drug, not only for the treatment of severe acne, but also for other diagnoses and in chemoprevention settings. Because the use of isotretinoin is increasing, it is important for physicians to be aware of the adverse events, toxicities, and management issues related to its use. The most important issue is that of congenital defects, which has resulted in new pregnancy prevention policies and programs implemented by the manufacturer. A relatively new concern is that of depression associated with isotretinoin use, also resulting in new policies placed by the manufacturer and the FDA. The most common adverse effects observed during treatment are mucocutaneous and ocular in nature, but laboratory abnormalities and effects in the nervous, musculoskeletal, gastrointestinal, pulmonary, hematologic, and other systems are also described. Additionally, potential drug interactions, follow-up, and toxicity prevention measures are discussed.
异维A酸（泰尔丝，罗氏制药公司，新泽西州纽特里）是一种重要药物，不仅用于治疗重度痤疮，还用于其他病症及化学预防。由于异维A酸的使用正在增加，医生了解与其使用相关的不良事件、毒性及管理问题很重要。最重要的问题是先天性缺陷，这导致生产商实施了新的预防怀孕政策和计划。一个相对较新的关注点是与异维A酸使用相关的抑郁症，这也促使生产商和美国食品药品监督管理局出台了新政策。治疗期间观察到的最常见不良反应本质上是皮肤黏膜和眼部的，但也描述了实验室异常以及对神经、肌肉骨骼、胃肠、肺部、血液及其他系统的影响。此外，还讨论了潜在的药物相互作用、随访及毒性预防措施。
