裂殖酵母中通过独特机制建立和维持姐妹染色单体黏连。
Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.
作者信息
Tanaka K, Hao Z, Kai M, Okayama H
机构信息
Department of Biochemistry and Molecular Biology, The University of Tokyo, Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
EMBO J. 2001 Oct 15;20(20):5779-90. doi: 10.1093/emboj/20.20.5779.
Abstract
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.
摘要
在S期，染色单体黏连仅在新生姐妹染色单体之间建立，并沿其整个区域进行精确配对，但如何确保这一点尚不清楚。在此我们报告，姐妹染色单体黏连是通过一种独特机制形成并维持的。在裂殖酵母中，与DNA复制紧密偶联发挥作用的Eso1p建立姐妹染色单体黏连，而新发现的黏连蛋白相关蛋白Pds5p会阻碍黏连的建立，直到被Eso1p抵消，但一旦黏连建立，它会使黏连稳定下来。Eso1p通过其Ctf7p/Eco1p同源结构域与Pds5p发生物理相互作用。
相似文献
1
Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism.
EMBO J. 2001 Oct 15;20(20):5779-90. doi: 10.1093/emboj/20.20.5779.
2
Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.
Mol Cell Biol. 2000 May;20(10):3459-69. doi: 10.1128/MCB.20.10.3459-3469.2000.
3
Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.
Genes Dev. 1998 Nov 1;12(21):3408-18. doi: 10.1101/gad.12.21.3408.
4
Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains.
Nucleic Acids Res. 2003 Nov 1;31(21):6334-43. doi: 10.1093/nar/gkg811.
5
The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion.
J Biol Chem. 2004 Nov 19;279(47):49542-50. doi: 10.1074/jbc.M404324200. Epub 2004 Sep 7.
6
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.
Genes Dev. 2000 Nov 1;14(21):2757-70. doi: 10.1101/gad.832000.
7
Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.
Genes Dev. 1999 Feb 1;13(3):320-33. doi: 10.1101/gad.13.3.320.
8
Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery.
Genes Dev. 1999 Feb 1;13(3):307-19. doi: 10.1101/gad.13.3.307.
9
Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism.
Cell Cycle. 2006 Nov 1;5(21):2528-36. doi: 10.4161/cc.5.21.3405. Epub 2006 Sep 13.
10
Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin.
Genes Cells. 2000 Jan;5(1):1-8. doi: 10.1046/j.1365-2443.2000.00306.x.
引用本文的文献
1
In through the out door: A loop-binding-first model for topological cohesin loading.
Bioessays. 2024 Oct;46(10):e2400120. doi: 10.1002/bies.202400120. Epub 2024 Aug 19.
2
ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells.
Nat Struct Mol Biol. 2023 Apr;30(4):436-450. doi: 10.1038/s41594-023-00929-5. Epub 2023 Mar 6.
3
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.
Epigenetics Chromatin. 2022 Aug 19;15(1):30. doi: 10.1186/s13072-022-00463-6.
4
Rec8 Cohesin: A Structural Platform for Shaping the Meiotic Chromosomes.
Genes (Basel). 2022 Jan 22;13(2):200. doi: 10.3390/genes13020200.
5
PCNA Loaders and Unloaders-One Ring That Rules Them All.
Genes (Basel). 2021 Nov 18;12(11):1812. doi: 10.3390/genes12111812.
6
Chromosomal Instability in Acute Myeloid Leukemia.
Cancers (Basel). 2021 May 28;13(11):2655. doi: 10.3390/cancers13112655.
7
PDS5A and PDS5B in Cohesin Function and Human Disease.
Int J Mol Sci. 2021 May 30;22(11):5868. doi: 10.3390/ijms22115868.
8
Linear elements are stable structures along the chromosome axis in fission yeast meiosis.
Chromosoma. 2021 Sep;130(2-3):149-162. doi: 10.1007/s00412-021-00757-w. Epub 2021 Apr 7.
9
Cohesin architecture and clustering in vivo.
Elife. 2021 Feb 17;10:e62243. doi: 10.7554/eLife.62243.
10
Effects of the microtubule nucleator Mto1 on chromosomal movement, DNA repair, and sister chromatid cohesion in fission yeast.
Mol Biol Cell. 2019 Oct 1;30(21):2695-2708. doi: 10.1091/mbc.E19-05-0301. Epub 2019 Sep 4.
本文引用的文献
1
A Monoclonal Antibody Against the PSTAIR Sequence of p34 , Catalytic Subunit of Maturation-Promoting Factor and Key Regulator of the Cell Cycle: (monoclonal antibody/PSTAIR sequence/oocyte maturation/cell cycle/cdc2).
Dev Growth Differ. 1991 Dec;33(6):617-624. doi: 10.1111/j.1440-169X.1991.00617.x.
2
Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.
Mol Cell. 2001 May;7(5):959-70. doi: 10.1016/s1097-2765(01)00254-4.
3
BimD/SPO76 is at the interface of cell cycle progression, chromosome morphogenesis, and recombination.
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6267-72. doi: 10.1073/pnas.081088498. Epub 2001 May 15.
4
Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion.
Mol Cell Biol. 2001 May;21(9):3144-58. doi: 10.1128/MCB.21.9.3144-3158.2001.
5
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination.
Nature. 2001 Jan 18;409(6818):359-63. doi: 10.1038/35053103.
6
Pds5 cooperates with cohesin in maintaining sister chromatid cohesion.
Curr Biol. 2000;10(24):1557-64. doi: 10.1016/s0960-9822(00)00854-x.
7
Characterization of vertebrate cohesin complexes and their regulation in prophase.
J Cell Biol. 2000 Nov 13;151(4):749-62. doi: 10.1083/jcb.151.4.749.
8
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.
Genes Dev. 2000 Nov 1;14(21):2757-70. doi: 10.1101/gad.832000.
9
Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae.
J Cell Biol. 2000 Oct 30;151(3):613-26. doi: 10.1083/jcb.151.3.613.
10
HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functions.
Genome Res. 2000 Oct;10(10):1445-52. doi: 10.1101/gr.147400.
Zotero 插件