Poonai N P, Antony M M, Binkley K E, Stenn P, Swinson R P, Corey P, Silverman F S, Tarlo S M
Gage Occupational and Environmental Health Unit, University of Toronto, 223 College Street, Toronto, Ontario, Canada M5T 1R4.
J Psychosom Res. 2001 Sep;51(3):537-41. doi: 10.1016/s0022-3999(01)00250-1.
Idiopathic environmental intolerance (IEI) is associated with unexplained symptoms attributed to non-noxious levels of environmental substances. Clinically, some of the symptoms of IEI overlap with those of panic disorder (PD). We have recently reported a link between IEI and panic responses to a single inhalation of 35% carbon dioxide (CO(2)), a reliable panic induction challenge. This study assessed depression, stress, anxiety, and agoraphobic symptoms among IEI subjects from our previous study versus healthy controls.
Thirty-six IEI and 37 control subjects with no preexisting psychiatric history were compared on self-report psychological questionnaires.
IEI subjects scored significantly higher than controls on the Agoraphobic Cognitions Questionnaire (ACQ), Depression Anxiety Stress Scales (DASS), and Mobility Inventory for Agoraphobia (MI) (Student's t, P<.05).
IEI subjects represent a group with morbidity significantly higher than a control population but less than what would be expected for a clinical psychiatric population.