[间歇性-Gx对尾部悬吊大鼠基底动脉反应性变化的对抗作用]
[Counteraction effect of intermittent -Gx on changes of responsiveness of basilar artery in tail-suspended rats].
作者信息
Zhang L N, Cheng J H, Ni H Y, Ma J, Zhang L F, Wu Y H
机构信息
Department of Aerospace Physiology, Xi'an 710032, China.
出版信息
Space Med Med Eng (Beijing). 2001 Aug;14(4):244-7.
OBJECTIVE
To investigate counteracting effects of intermittent -Gx exposure on changes of responsiveness of basilar artery in tall-suspended rats.
METHOD
Rats tail-suspended for 3 wk were daily subjected to 1 h 1.5 G or 2.6 G centrifugation, simulating -Gx exposure of various G values. Responses of perfused isolated basilar arterial rings to KCl was examined.
RESULT
Maximal isometric contractile response to KCl were significantly enhanced in arterial rings isolated from 3 wk tail-suspended rats as compared with that from simultaneous control rats (P < 0. 05). However, maximal isometric contractile responses to KCl of arterial rings isolated from 3 wk tail-suspended plus daily -Gx exposure rats were no difference as compared with that from simultaneous control rats, and were significantly decreased (P < 0.05) as compared with that from 3 wk tail-suspended rats.
CONCLUSION
Daily intermittent -Gx exposure as a countermeasure to prevent the effects of simulated weightless on changes in responsiveness of basilar artery from tail-suspended rats was valid.
目的
探讨间歇性-Gx暴露对高悬吊大鼠基底动脉反应性变化的对抗作用。
方法
将悬吊3周的大鼠每天进行1小时的1.5G或2.6G离心，模拟不同G值的-Gx暴露。检测灌注离体基底动脉环对氯化钾的反应。
结果
与同期对照大鼠相比，从悬吊3周的大鼠分离出的动脉环对氯化钾的最大等长收缩反应显著增强（P<0.05）。然而，与同期对照大鼠相比，从悬吊3周并每日进行-Gx暴露的大鼠分离出的动脉环对氯化钾的最大等长收缩反应无差异，且与悬吊3周的大鼠相比显著降低（P<0.05）。
结论
每日间歇性-Gx暴露作为一种对抗措施，可有效预防模拟失重对悬吊大鼠基底动脉反应性变化的影响。
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