Hofmeyr G J
(Director, Effective Care Research Unit, University of the Witwatersrand), Frere/Cecilia Makiwane Hospitals, Private Bag 9047, East London 5200, Eastern Cape, South Africa.
Cochrane Database Syst Rev. 2001(4):CD000184. doi: 10.1002/14651858.CD000184.
Tocolytic drugs to relax the uterus as well as other methods have been also used in an attempt to facilitate external cephalic version at term.
The objective of this review is to assess the effects of routine tocolysis, fetal acoustic stimulation, epidural or spinal analgesia and transabdominal amnioinfusion for external cephalic version at term on successful version and measures of pregnancy outcome.
The Cochrane Pregnancy and Childbirth Group Trials Register and the Cochrane Controlled Trials Register were searched. Date of last search: April 2001.
Randomised and quasi-randomised trials comparing routine versus selective tocolysis; fetal acoustic stimulation in midline fetal spine positions versus dummy or no stimulation; epidural or spinal analgesia versus no regional analgesia; or transabdominal amnioinfusion versus no amnioinfusion for external cephalic version at term.
Eligibility and trial quality were assessed by the reviewer.
In seven trials, routine tocolysis was associated with fewer failures of external cephalic version (relative risk 0.74, 95% confidence interval 0.64 to 0.87). There were no significant differences between non-cephalic presentations at birth. Caesarean sections were reduced (relative risk 0.85, confidence interval 0.72-0.99). Fetal acoustic stimulation in midline fetal spine positions was associated with fewer failures of external cephalic version at term (relative risk 0.17, 95% confidence interval 0.05 to 0.60). With epidural or spinal analgesia, external cephalic version failure, non-cephalic births and caesarean sections were reduced in one trial but not the other. The overall differences were not statistically significant. No randomised trials of transabdominal amnioinfusion for external cephalic version at term were located.
REVIEWER'S CONCLUSIONS: Routine tocolysis appears to reduce the failure rate of external cephalic version at term. Although promising, there is not enough evidence to evaluate the use of fetal acoustic stimulation in midline fetal spine positions, nor of epidural or spinal analgesia. Large volume intravenous preloading may have contributed to the effectiveness demonstrated in one of the latter trials. No randomised trials of transabdominal amnioinfusion for external cephalic version at term were found.
为了便于足月时进行外倒转术,人们也使用了使子宫松弛的宫缩抑制剂以及其他方法。
本综述的目的是评估足月时进行外倒转术时,常规使用宫缩抑制剂、胎儿声刺激、硬膜外或脊髓镇痛以及经腹羊膜腔灌注对成功倒转及妊娠结局指标的影响。
检索了Cochrane妊娠与分娩组试验注册库和Cochrane对照试验注册库。最后检索日期:2001年4月。
比较常规与选择性使用宫缩抑制剂;胎儿脊柱中线位置的胎儿声刺激与假刺激或无刺激;硬膜外或脊髓镇痛与无区域镇痛;或足月时进行外倒转术时经腹羊膜腔灌注与无羊膜腔灌注的随机和半随机试验。
由综述作者评估纳入标准和试验质量。
在7项试验中,常规使用宫缩抑制剂与外倒转术失败次数较少相关(相对危险度0.74,95%置信区间0.64至0.87)。出生时非头位表现无显著差异。剖宫产率降低(相对危险度0.85,置信区间0.72 - 0.99)。胎儿脊柱中线位置的胎儿声刺激与足月时外倒转术失败次数较少相关(相对危险度0.17,95%置信区间0.05至0.60)。使用硬膜外或脊髓镇痛时,一项试验中外倒转术失败、非头位分娩和剖宫产率降低,但另一项试验未降低。总体差异无统计学意义。未找到足月时进行外倒转术经腹羊膜腔灌注的随机试验。
常规使用宫缩抑制剂似乎可降低足月时外倒转术的失败率。尽管前景乐观,但尚无足够证据评估胎儿脊柱中线位置的胎儿声刺激以及硬膜外或脊髓镇痛的使用情况。大容量静脉预负荷可能促成了后一项试验中显示出的有效性。未找到足月时进行外倒转术经腹羊膜腔灌注的随机试验。