Facchini M, Bauersfeld U, Fasnacht M, Candinas R
Rhythmologie Abteilung, Universitätsspital Zürich.
Schweiz Med Wochenschr. 2000 Dec 23;130(51-52):1962-9.
During pregnancy an increased incidence of maternal cardiac arrhythmias is observed. These include a wide spectrum, from clinically irrelevant isolated premature beats to debilitating supraventricular and ventricular tachycardias. In principle, management of arrhythmias during pregnancy is similar to that in non-pregnant patients. However, special consideration should be given to foetal age and potential teratogenic and haemodynamic adverse drug effects on the foetus. Therapeutic strategy should be guided by interdisciplinary consulting (i.e. cardiology, obstetrics, neonatology). Diagnostic evaluation must rule out underlying cardiovascular, pulmonary, endocrine or metabolic diseases. Additionally, precipitating factors such as excessive caffeine and/or alcohol ingestion and cigarette smoking should be avoided. For benign arrhythmias a conservative approach is appropriate. Antiarrhythmic drug selection depends on the specific arrhythmia being treated and the cardiac condition of the mother and the foetus. Some antiarrhythmic agents, such as propranolol, metoprolol, digoxin and quinidine, have been extensively tested during pregnancy and have proven to be safe; they should therefore, whenever possible, be used as firstline. For supraventricular tachycardia, intravenous adenosine may be used to terminate the arrhythmia if vagal manoeuvres fail. In emergency situations cardioversion may be performed with relative safety. Implantable cardioverter defibrillators as a preventive measure for life-threatening arrhythmias in pregnant patients do not seem to increase the risk of major complications.
孕期母体心律失常的发生率会增加。这些心律失常种类繁多,从临床上无关紧要的孤立早搏到使人虚弱的室上性和室性心动过速。原则上,孕期心律失常的管理与非孕期患者相似。然而,应特别考虑胎儿年龄以及药物对胎儿潜在的致畸和血流动力学不良影响。治疗策略应以多学科会诊(即心脏病学、产科学、新生儿学)为指导。诊断评估必须排除潜在的心血管、肺部、内分泌或代谢疾病。此外,应避免诸如过量摄入咖啡因和/或酒精以及吸烟等诱发因素。对于良性心律失常,采取保守方法是合适的。抗心律失常药物的选择取决于所治疗的特定心律失常以及母亲和胎儿的心脏状况。一些抗心律失常药物,如普萘洛尔、美托洛尔、地高辛和奎尼丁,在孕期已进行了广泛测试,且已证明是安全的;因此,只要有可能,应将它们用作一线药物。对于室上性心动过速,如果迷走神经手法无效,可使用静脉腺苷来终止心律失常。在紧急情况下,心脏复律可相对安全地进行。植入式心脏复律除颤器作为孕期患者危及生命的心律失常的预防措施,似乎不会增加重大并发症的风险。