Turner K J, Baldo B A, Anderson H R
Int Arch Allergy Appl Immunol. 1975;48(6):784-99.
Serum IgE levels in adults from the Highland area of Papua-New Guinea were considerably elevated above those found for Caucasian residents in Australia and most Western countries. The median IgE value for the asthmatic group in New Guinea was significantly (p less than 0.01) elevated above that of control subjects. Identification of IgE antibodies by the radio-allergosorbent test to house dust mite showed an 85-percent correlation with the results of skin reactions to extracts of the mite. 90% of the asthmatic subjects had IgE antibodies to Dermatophagoides pteronyssinus compared with 23% of patients with chronic obstructive lung disease and 6% of controls (p less than 0.0001). No significant difference was found in the incidence of IgE antibodies to Ascaris lumbricoides in asthmatic versus control subjects but the incidence was elevated (p less than 0.005) in patients with chronic obstructive lung disease. Apparently hypersensitivity to Ascaris is not a factor of importance in the aetiology of asthma in New Guinea.
巴布亚新几内亚高地地区成年人的血清免疫球蛋白E（IgE）水平显著高于澳大利亚和大多数西方国家的白种居民。新几内亚哮喘组的IgE中值显著高于对照组（p<0.01）。通过放射变应原吸附试验检测针对屋尘螨的IgE抗体，结果显示与对螨提取物的皮肤反应结果有85%的相关性。90%的哮喘患者有针对粉尘螨的IgE抗体，相比之下，慢性阻塞性肺病患者的这一比例为23%，对照组为6%（p<0.0001）。哮喘患者与对照组相比，针对蛔虫的IgE抗体发生率无显著差异，但慢性阻塞性肺病患者的发生率升高（p<0.005）。显然，对蛔虫的超敏反应在新几内亚哮喘病因中并非重要因素。
